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--> Frontier Research Institute for Interdisciplinary SciencesTohoku University Directions 日本語 English CONTACT 日本語 English About FRISGreetingsOverviewMissionsOrganizationTenure track system in FRISMaps & DirectionsPublicationAnnual MeetingAbstract for Annual MeetingConsultation DeskResearcherAdvanced Interdisciplinary Research DivisionHiroshi MasumotoTakehito ShimatsuTakashi ItohKenji TomaShinsuke NiwaTakaaki TomaiCreative Interdisciplinary Research DivisionYuanyuan GuoMasaki OkumuraNguyen Tuan HungHiroshi UenoToshiharu IchinoseYuta KudoHiroya AbeYuta NakayasuNaoya KitajimaDaniel Pastor-GalanYasunori OkamotoTakuro IshiiMasaki YamadaYuta YamaneKexin XiongKohei ShimokawaShinichi SatoKotaro YasuiSUN SaiYuji SaitoAtsushi TaharaKyoko ChibaYuka HatanoHakuto SuzukiKaoru HiramotoHideaki T. MatsubayashiAseel Mahmoud Suleiman MarahlehSakura KiuchiShigeo S. KimuraBin Ho LeTom WellingHiroyuki UechiFumi MurakoshiChao TangTakahiro ChibaIzumi MatsudairaYuka FujikiLinda ZhangYueh Hsuan WengManaging & Planning DivisionJunji SaidaHideaki FujiwaraEndowed Research DivisionsSenior-advisorTomoyuki YamayaVisiting Professors / Collaborative ResearchersSpecially-appointedOne-time membersSeiji KojimaDaisuke SuzukiHidenobu YajimaHirokazu KawamuraShozo FurumotoKanako ShojikiYiwen ZhangYuiko Morita-FujimuraPierre Antoine GESLINYuma TakahashiTatsuya SatoYuki FuruseKim Sung HoonYui ArimatsuYuichiro FujiokaRui NouchiAyako NakamuraNozomi SaitoTetsuya KajitaHiroyasu HatakeyamaYuki ShibazakiSohei TasakiHitomi AnzaiYuji ShimogonyaHideaki YamamotoHiroki TakikawaTakeshi InoueTakashi MisakaMikito TanakaGao JunhongNaoya OnizawaYasufumi ArakiDaisuke SaitoShusaku SugimotoMasafumi NakayamaHirofumi NodaMasanori IzumiMichiko KanoKohji TsumuraKenichi FunamotoMasahiro KayamaAtsushi NarukoShinsuke SuzukiGen HayaseDaisuke YoshinoTakashi ShimonishiHisashi InoueTakayuki KojimaNobuyuki MatsumotoSeiji KamadaSae KanekoTomoki KimuraYuichiro NakajimaShimpei EndoRui YamadaHisashi KinoYuki Suzuki Fumihiro KanedaYuji NashimotoYusuke SatoShuhei ObaraYasukazu DaigakuHanae AokiHiroki IdaAlimu TuohetiKaoru KakinumaJoji KusuyamaJiuhui HanYang CaoJun ZhangKohei TamuraChaoliang ZhangTomokatsu OnagaMasanori WakizakaKohei IchikawaTomomi TsunematsuChrystelle BERNARDKozue ShiomiYohei KawazuraSatoshi IihamaTakuya MabuchiFeatureTopicsFRIS InterviewsFRIS Interviews #01FRIS Interviews #02FRIS Interviews #03FRIS Interviews #04FRIS Interviews #05FRIS Interviews #06FRIS Interviews #07FRIS Interviews #08FRIS Interviews #09FRIS Interviews #10FRIS Interviews #11FRIS Interviews #12FRIS Interviews #13FRIS Interviews #14FRIS Interviews #15FRIS Interviews #16FRIS Hub MeetingFRIS Hub Meeting 2024FRIS Hub Meeting 2023FRIS Hub Meeting2022FRIS Hub Meeting2021FRIS Hub Meeting archiveProgramsOpen Research ProposalResearch ProjectsRecruitOpen Staff PositionsFRIS Regulations pertaining to the tenure track systemHandbook for International ResearchersFRIS FundFRIS Fund for Early-Career Independent ResearchersLINK Researcher HOME en Researcher Creative Interdisciplinary Research Division Sakura Kiuchi ResearcherAdvanced Interdisciplinary Research DivisionCreative Interdisciplinary Research DivisionManaging & Planning DivisionEndowed Research DivisionsSenior-advisorVisiting Professors / Collaborative ResearchersSpecially-appointedOne-time members Sakura Kiuchi Assistant ProfessorHuman and Society Mentor Information Professor Ken Osaka (School of Dentistry) researchmap 東北大学研究者紹介--> ウェブサイト--> Research Fields Preventive dentistry, Public health Research Subjects Relationship between Oral Status and Cognitive Function Social determinants of oral health Academic Society Membership Japanese Society of Public Health, The Japanese Society for Oral health, Japan Epidemiological Association, The International Association for Dental Research Research Outline   Oral diseases are highly prevalent among 3.5 billion people worldwide. Focusing on the importance of oral health with a large burden, I have researched the relationship between oral health and general health, especially cognitive function, using large-scale questionnaires and medical data. Previous studies found the relationship between oral health and dementia; however, the overall mechanism has been still unclear. Some studies have suggested possible mechanisms such as the effects of inflammation caused by periodontal disease, decreased cerebral blood flow due to low occlusal stimulation, and nutritional deficiency. In addition, poor oral condition may lead to reduced social activity due to difficulty in speaking, smiling, and eating the same foods as others. Therefore, the social pathways currently have been focused on. I revealed the partial pathways of social and nutritional pathways between oral health and dementia using large-scale Japanese cohort data from the Japan Gerontological Evaluation Study (JAGES). In FRIS, I would like to investigate what kind of people with oral conditions could lead to cognitive impairment using causal inference methods, machine learning, and conventional statistical analysis methods. Through this research, I will try to elucidate the mechanism of the relationship between oral status and cognitive function and aimed to build a healthy society to prevent the progression of dementia and reduce the burden of healthcare costs from oral health. 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