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You are using an outdated browser. Please upgrade your browser to improve your experience. KYOTO UNIVERSITY KUIASDistinguished Professors / ResearchersProfile：Mitinori Saitou 日本語 English Kyoto UniversityInstitute for Advanced Study About KUIAS Message Distinguished Professors / Researchers News Access menu Profile：Mitinori Saitou Mitinori Saitou Professor and ASHBi Director View more details Research Fields Developmental Biology, Cell Biology Research Overview Saitou has been promoting studies on the developmental mechanisms of germ cells, the origin of all life. He clarified the formation mechanisms of mouse germ cells and successfully generated primordial germ cell-like cells (PGCLCs) in vitro from mouse ESCs and iPSCs to produce sperm, oocytes and healthy offspring. He used this experimental system as a model to investigate the molecular mechanisms of key phenomena in germ cell development, including epigenomic reprogramming, oocyte differentiation, and meiosis induction mechanisms. Saitou’s analysis of the developmental mechanisms of cynomolgus monkeys has allowed us to identify the characteristics of pluripotent cell lineages in mice, monkeys and humans and the formation mechanisms of germ cells in primates. He has also generated PGCLCs and oogonium from human iPSCs and pioneered research on in vitro reconstitution in the process of human germ cell development.   Saitou aims to promote advanced human biology that develops these studies, to identify the characteristics and evolutionary mechanisms of humans and primates, and to lay out new possibilities in medical science. Biography 1995 M.D., Kyoto University 1999 Ph.D., Kyoto University 1999-2003 Travelling Research Fellow/Senior Research Associate, Wellcome Trust/Cancer Research UK Gurdon Institute for Developmental Biology and Cancer 2003-2009 Team leader, RIKEN Center for Developmental Biology 2009-2018 Professor, Graduate School of Medicine and Faculty of Medicine, Kyoto University 2011-2018 Director, JST Strategic Basic Research Programs ERATO 2013-2018 Adjunct Principal Investigator, Institute for Integrated Cell-Material Sciences, Kyoto University 2018- Guest Principal Investigator, Center for iPS Cell Research and Application, Kyoto University 2018- Professor of KUIAS Director of Institute for the Advanced Study of Human Biology, KUIAS Selected Papers Saitou, M., Barton, S. C., and Surani, M. A. A molecular programme for the specification of germ cell fate in mice. Nature, 418, 293-300 (2002). Ohinata, Y., Ohta, H., Shigeta, M., Yamanaka, K., Wakayama, T., and Saitou, M. A signaling principle for the specification of the germ cell lineage in mice. Cell, 137, 571-584 (2009). Hayashi, K., Ohta, H., Kurimoto, K., Aramaki, S., and Saitou, M. Reconstitution of the mouse germ cell specification pathway in culture by pluripotent stem cells. Cell, 146, 519-532 (2011). Nakamura, T., Okamoto, I., Sasaki, K., Yabuta, Y., Iwatani, C., Tsuchiya, H., Seita, Y., Nakamura, S., Yamamoto, T., and Saitou, M. A developmental coordinate of pluripotency among mice, monkeys, and humans, Nature, 537, 57-62 (2016). Yamashiro, C., Sasaki, K., Yabuta, Y., Kojima, Y., Nakamura, T., Okamoto, I., Yokobayashi, S., Murase, Y., Ishikura, Y., Shirane, K., Sasaki, H., Yamamoto, T., and Saitou, M. Generation of human oogonia from induced pluripotent stem cells in vitro, Science, 362, 356-360 (2018). Honors Osaka Science Prize (2013), Japan Academy Medal, JSPS Prize (2014), Takeda Medical Prize (2016), Academic Award of the Mochida Memorial Foundation (2018), Asahi Prize, Uehara Prize (2019), Imperial Prize and Japan Academy Prize, ISSCR Momentum Award, EMBO Associate Member (2020) KUIAS Kyoto University Institute for Advanced StudyYoshida Ushinomiya-cho, Sakyo-ku, Kyoto 606-8501, Japan Phone： 075-753-9753 Fax： 075-753-9759 About KUIAS News Message Access Distinguished Professors / Researchers Member's Site --> Copyright © Kyoto University Institute for Advanced Study. All rights reserved. About KUIAS Message Distinguished Professors / Researchers News Access 日本語 ／ En